Vitamin D deficiency has been clinically associated with a variety of autoimmune diseases including rheumatoid arthritis, multiple sclerosis, insulin-dependent diabetes and inflammatory bowel disease. While a comprehensive understanding of the correlation between vitamin D deficiency and autoimmune disease remains elusive, data suggest a role for vitamin D in the development of self-tolerance, which prevents the immune system from attacking normal healthy cells. Individuals suffering from autoimmune diseases can benefit from prescription vitamin D drugs like Ortho D.
Vitamin D regulates T helper cells of the immune system resulting in a decrease in the T helper cell mediated autoimmune response. This regulation decreases T helper cells proclivity for attacking non-diseased cells in the human body. Targeted destruction of self-tissues is a characteristic condition of the approximately 80 autoimmune diseases known to afflict humans. Patients with autoimmune disease or patients at risk for developing such disease due to genetic factors may have an increased need for vitamin D making optimized supplementation critical to alleviating or preventing autoimmune symptoms.
Diet alone is an unreliable source of acquiring sufficient levels of vitamin D because most foods contain minimal quantities of this essential vitamin. While exposure to sunlight increases levels of vitamin D, this is a not a recommended means of achieving the recommended serum levels of the vitamin given the risk of skin cancer and premature aging.
Evidence for the relation of vitamin D deficiency and autoimmune disorder come from both environmental and genetic implications. Multiple Sclerosis (MS) is more prevalent in northern hemispheric regions where sunlight is less abundant and symptoms of MS increase during seasons of low sunlight. Additionally, patients with autoimmune disease have increased levels of mutations in vitamin D regulating genes as well as mutations in the vitamin D receptor and mutations in vitamin D binding proteins.
Cells involved in the immune response including macrophages, dendritic cells, T Cells and B Cells all express the vitamin D receptor (VDR). Agonistic interaction with endogenous VDRs on these cells likely plays a multifaceted role in the regulation of autoimmune responses. It is hypothesized that synthetic VDR agonists could be utilized to enable a variety of anti-proliferative, pro-differentiative, antibacterial, immunomodulatory and anti-inflammatory properties that would prove useful in attenuating immune cell response in a variety of autoimmune diseases.
The severity of interplay between vitamin D deficiency and autoimmune disorder warrants intervention beyond over-the-counter vitamin supplementation. Formulated vitamin D therapeutics that offer enhanced uptake and increased bioavailability should be considered for patients suffering from more than just the typical vitamin D deficiency widely correlated with a dietary deficiency. Ortho D capsules demonstrate enhanced efficacy in ameliorating the autoimmune related symptoms of hypovitaminosis D when compared to results obtained from over-the-counter supplementation. Awareness of this among physicians may lead to more doctors prescribing Ortho D as a cost-effective therapeutic to ameliorate symptoms among patients in dire need of normalized serum vitamin D levels.
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